Yeah I did that too in the past, but my experience was that since you had to accelerate the movement and use the longer travel, the accuracy decreased in the arm movements required increased. So to me, it came with unnecessary and fatigue and sometimes joint pain, Are you a significant compromise in ergonomics.
That said My work Monitor is a 34 inch uptra wide screen, And most of the radiology softwares are optimize for mice.
The most fascinating pointing devices I’ve ever seen are the vertical mice which are designed to avoid placing any pressure on the carpal ligament. Carpal tunnel syndrome is a bitch and its really common, just underdiagnosed.