I think the Vision Pro's tougest sell will be as a replacement for a multi-monitor desktop setup.
1) Typically, people who have multi-monitor desktop setups employ them for all-day use. I personally can lose track of time and forget to take breaks with my current 3-monitor setup, which is only possible because I feel no fatigue using it for an extended period of time (plus with different monitors you need to turn your head and change your focus distance, even though I have them "curved" around me, as it typical). I would expect using AR is going to be inherently more fatiguing, even with frequent breaks:
a) With AR you have an unavoidable vergence-accommodation conflict (VAC). Apple's Vision Pro has methods to mitigate that, but I don't think they'll be able to eliminate it entirely.
I also wonder if this would be exacerbated if you had to work with very small fonts in order to display all your data. Plus, when I need to do that, I'll just move my head closer to the screen to read them, since I don't want to give up displaying the whole spreadsheet, and thus don't want to zoom. Can you "move your head closer" with the Vision Pro?
b) The weight.
c) Just having something resting on your face.
2) It won't be able to offer the tactile feedback, and precision, of a physical keyboard.
So their picture of people working in offices using this in place of a traditional desktop setup seems like a reach--unless those folks are doing 3D design work; and even there I don't think they'd want to do most of their work using AR; it would just be too fatiguing..
Where it would make much more sense for office-type work, at least for me, would be if you are working remotely, and thus have only a laptop, but the laptop's screen is much too small for the work you need to do. There, if you connected it to the laptop, you'd have the physical keyboard and trackpad, and the significant increase in monitor real estate would be worth the tradeoff.
Finally, I'd be interested to see how sharp this really is. It's supposed to offer pixels-per-degree comparable to that of a Retina external display at normal viewing distances. But if you are dealing with small fonts, is it really as sharp? E.g., do you lose some sharpness because of VAC?