And not even good, old fashioned hamsters. It won’t matter to Joe fans though.
Actually non-clinical testing can include animals, but not if you’re testing for clinical outcomes, i.e. using hamsters to see if ivermectin is effective in reducing COVID-19 cases or deaths or whatever metric chosen. Non-clinical trials with animals are used to investigate things like a drug’s basic pharmacological properties- absorption and distribution properties, how it’s metabolized and eliminated, it’s pharmacodynamics, toxicology profile, etc.
Based on what the article said and the fact we have known the basic properties of ivermectin for 40+ years or whatever, it suggests that this scientist was doing in-vitro testing aka test tube studies, in this case probably looking at how much drug is required to kill the virus.
What people typically don’t understand is that there is not only a requirement to have a high enough enough concentration of the drug for it to be effective, but you actually have to get the drug to the right place too. And there is a limit to how much of a specific drug you can get into a “compartment”- consider the bloodstream one compartment and the lungs another compartment and the brain another, etc. Drug concentrations are not necessarily equal between compartments.
For example Imodium, the OTC diarrhea medicine, it’s an opioid but it doesn’t kill pain or get you high. It’s chemical properties prevent it from moving from the blood stream into the brain where it would cause those effects.
With ivermectin, you’d never be able to get the required concentration of drug into the lung tissue to treat COVID. The half-maximal inhibitory concentration of Ivermectin is orders of magnitude higher than the maximum concentration of drug attainable in lung tissue. In fact, the amount of ivermectin required is something like 35x higher than can be absorbed into the bloodstream through oral route of administration. There is no intravenous ivermectin either, at least approved for human use.
Like I said, the pharmacological properties of ivermectin are well established. It should have been evident from the first in vivo study that the concentration required for COVID treatment is not only toxic but physically unattainable in the human body.