So, just to be clear, the Hydroxychloroquine story is much less asinine than the IV disinfectant insanity.
The reason HC initially generated a lot of hope was that it had been shown to block entry of the SARS-CoV
-1 virus into cells (isolated from the original early 2000s SARS epidemic).
People were so desperate to find any treatment for Covid-19 (= SARS-CoV
-2) that many immediately jumped on it, and were encouraged by rapid in vitro experiments showing HC also inhibited SARS-CoV
-2 from entering cells. Many trials were rapidly started started across the world. Unfortunately, they failed to show any useful impact on the disease.
The problem turned out to be that the viral cell-entry mechanism blocked by HC involved an acidic protease (HC increases the cellular pH). Turns out, SARS-CoV
-1 depends on that protease to get in, SARS-CoV
-2 does NOT, since can use a different, pH insensitive protease (TMPRSS2) to get in, making HC useless against SARS-CoV
-2.
To confound the issue even more, the cell lines most widely used in labs for viral work lacked TMPRSS2, making SARS-CoV
-2 look dependent of the HC-sensitive acidic protease, so the initial lab reports on using HC were very "promising", and only refuted once human cell lines carrying TMPRSS2 were tested...
Obviously, science does not influence the political debate...